>> HOMEPAGE

AIDS Research

Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines.

J Biol Chem 1997 Feb 28;272(9):5814-20 (ISSN: 0021-9258)

Rivas CI; Vera JC; Guaiquil VH; Velasquez FV; Borquez-Ojeda OA; Carcamo JG; Concha II; Golde DW Program in Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Vitamin C (ascorbic acid) is required for normal host defense and functions importantly in cellular redox systems. To define the interrelationship between human immunodeficiency virus (HIV) infection and vitamin C flux at the cellular level, we analyzed vitamin C uptake and its effects on virus production and cellular proliferation in HIV-infected and uninfected human lymphoid, myeloid, and mononuclear phagocyte cell lines. Chronic or acute infection of these cell lines by HIV-1 led to increased expression of glucose transporter 1, associated with increased transport and accumulation of vitamin C. Infected cells also showed increased transport of glucose analogs. Exposure to vitamin C had a complex effect on cell proliferation and viral production. Low concentrations of vitamin C increased or decreased cell proliferation depending on the cell line and either had no effect or caused increased viral production. Exposure to high concentrations of vitamin C preferentially decreased the proliferation and survival of the HIV-infected cells and caused decreased viral production. These findings indicate that HIV infection in lymphocytic, monocytic, and myeloid cell lines leads to increased expression of glucose transporter 1 and consequent increased cellular vitamin C uptake. High concentrations of vitamin C were preferentially toxic to HIV-infected host defense cell lines in vitro.

Sitemap

Was ist neu:

Lehren aus der tödlichen Viagra-Studie an Schwangeren: Sichere, natürliche Alternativen sollten bei klinischen Versuchen Vorrang haben

Gates-Stiftung unterstützt Plan zur globalen „Harmonisierung von Nährstoffgrenzen“ in Ergänzungsmitteln

Natürliche Behandlung von Immunschwächekrankheiten

Die Geschichte des Pharma-Kartells

Mikronährstoffe können vor Zellschäden durch Strahlung schützen

Bildgebende Diagnostik kann in Zellen Strahlungsschäden verursachen

Erhöhte Cholesterinspiegel natürlich senken, ohne Medikamente

Herzrhythmusstörungen auf natürliche Weise vorbeugen bzw. korrigieren

Niereninsuffizienz und deren natürlicher Behandlungsansatz

ADHS natürlich behandeln

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2018 Dr. Rath Health Foundation | Kontakt | Impressum | Nutzungsbedingungen | Datenschutzerklärung | RSS Feed