>> HOMEPAGE

AIDS Research

Virological and immunological effects of antioxidant treatment in patients with HIV infection.

Eur J Clin Invest 2000 Oct;30(10):905-14 (ISSN: 0014-2972)

Muller F; Svardal AM; Nordoy I; Berge RK; Aukrust P; Froland SS University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway. fredrik.muller@labmed.uio.no.

BACKGROUND: Intracellular oxidative stress in CD4+ lymphocytes due to disturbed glutathione homeostasis may lead to impaired lymphocyte functions and enhanced HIV replication in patients with HIV infection, especially in those with advanced immunodeficiency. The aim of the present study was to assess whether short-term, high-dose antioxidant treatment might have effects on immunological and virological parameters in patients with HIV infection. MATERIALS AND METHODS: In this pilot study, we examined virological and immunological effects of antioxidant combination treatment for 6 days with high doses of N-acetylcysteine (NAC) and vitamin C in 8 patients with HIV infection. The following were assayed before, during and after antioxidant treatment: HIV RNA plasma levels; numbers of CD4+, CD8+, and CD14+ leukocytes in blood; plasma thiols; intracellular glutathione redox status in CD4+ lymphocytes and CD14+ monocytes; lymphocyte proliferation; lymphocyte apoptosis and plasma levels of tumour necrosis factor (TNF)alpha; soluble TNF receptors and neopterin in plasma. RESULTS: No significant changes in HIV RNA plasma levels or CD4+ lymphocyte counts in blood were noted during antioxidant treatment in the patient group. However, in the 5 patients with the most advanced immunodeficiency (CD4+ lymphocyte counts < 200 x 106 L(-1)), a significant rise in CD4+ lymphocyte count, a reduction in HIV RNA plasma level of 0.8 log, an enhanced lymphocyte proliferation and an increased level of intracellular glutathione in CD4+ lymphocytes were found. No change in lymphocyte apoptosis was noted. CONCLUSIONS: Short-term, high-dose combination treatment with NAC and vitamin C in patients with HIV infection and advanced immunodeficiency lead to immunological and virological effects that might be of therapeutic value.

Sitemap

Was ist neu:

Professor der Stanford Universität sieht Zusammenbruch des Öl-Kartells näher rücken

Bereits einwöchiger Gebrauch üblicher Schmerzmittel steigert das Risiko auf Herzinfarkt

Neue klinische Übersichtsarbeit erkennt in Sonnenschutzmitteln die Ursache für weit verbreiteten Vitamin D-Mangel

Aufsichtsbehörden der Brüsseler EU ignorieren unverhohlen die Giftwirkungen von Pestizid-Cocktails in Nahrungsmitteln

Internationales Tribunal bezichtigt Monsanto des ›Ökozids‹

Wer weiß, was das Beste für Ihre Kinder ist? Sie? Oder die Regierung?

Daueranwendung von Antibiotika kann Darmkrebs-Risiko erhöhen

Niedergang der Brüsseler EU rückt näher

David Rockefeller mit 101 verstorben: Nachrufe in den Medien unterschlagen seine zentrale Rolle in der Bilderberg-Gruppe

Hochdosierte B-Vitamine haben laut Studie Schutzwirkung gegen verschmutzte Luft

Neue Hiobsbotschaften für die Pharma: Bisphosphonat-Medikamente gegen Osteoporose SCHWÄCHEN die Knochen!

>> Natürliche Gesundheit

>> "Geschäft m. d. Krankheit"

>> Internationale Kampagne

>> Dr. Raths Offene Briefe

>> Studien weltweit

>> Studien auf Deutsch

>> Helfen Sie mit!

>> Codex Alimentarius

>> Dossiers

>> Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2017 Dr. Rath Health Foundation | Kontakt | Impressum | RSS Feed