>> HOMEPAGE

Aids Research

Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus.

American journal of hematology; VOL: 49 (4); p. 318-22

Paltiel O; Falutz J; Veilleux M; Rosenblatt DS; Gordon K

OBJECTIVES: To determine the prevalence and describe the clinical correlates of subnormal cobalamin levels in subjects infected with the human immunodeficiency virus (HIV), and to assess its relationship to virus-mediated immunosuppression and/or anti-viral therapy. SETTING: Outpatient referral clinic in tertiary care hospital. PATIENT POPULATION: 200 HIV infected individuals. STUDY DESIGN: Descriptive cross sectional survey, with prospective follow-up in a subgroup of patients before and after initiation of zidovudine therapy. MEASURES: Routine complete blood count, serum B12 assay, CD4 counts. Serum homocysteine levels, and Schilling tests were performed on subgroups of study subjects. RESULTS: Subnormal serum B12 levels were found in 61 subjects (30.5%). B12 deficient subjects were more likely to be taking zidovudine. (P = .007). Serum homocysteine levels were significantly higher in patients with subnormal cobalamin levels but were unrelated to CD4 counts or zidovudine use, and were rarely outside of the normal range. Malabsorption of vitamin B12 as evidenced by abnormal Schilling tests was more likely among patients with more advanced HIV disease, or gastrointestinal symptoms but was not necessarily associated with low B12 levels. CONCLUSIONS: Decreased cobalamin levels are found frequently in HIV disease, especially among those treated with zidovudine. Evidence of B12 malabsorption is found among those with more advanced disease and gastrointestinal symptoms.

Sitemap

Was ist neu:

Professor der Stanford Universität sieht Zusammenbruch des Öl-Kartells näher rücken

Bereits einwöchiger Gebrauch üblicher Schmerzmittel steigert das Risiko auf Herzinfarkt

Neue klinische Übersichtsarbeit erkennt in Sonnenschutzmitteln die Ursache für weit verbreiteten Vitamin D-Mangel

Aufsichtsbehörden der Brüsseler EU ignorieren unverhohlen die Giftwirkungen von Pestizid-Cocktails in Nahrungsmitteln

Internationales Tribunal bezichtigt Monsanto des ›Ökozids‹

Wer weiß, was das Beste für Ihre Kinder ist? Sie? Oder die Regierung?

Daueranwendung von Antibiotika kann Darmkrebs-Risiko erhöhen

Niedergang der Brüsseler EU rückt näher

David Rockefeller mit 101 verstorben: Nachrufe in den Medien unterschlagen seine zentrale Rolle in der Bilderberg-Gruppe

Hochdosierte B-Vitamine haben laut Studie Schutzwirkung gegen verschmutzte Luft

Neue Hiobsbotschaften für die Pharma: Bisphosphonat-Medikamente gegen Osteoporose SCHWÄCHEN die Knochen!

>> Natürliche Gesundheit

>> "Geschäft m. d. Krankheit"

>> Internationale Kampagne

>> Dr. Raths Offene Briefe

>> Studien weltweit

>> Studien auf Deutsch

>> Helfen Sie mit!

>> Codex Alimentarius

>> Dossiers

>> Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2017 Dr. Rath Health Foundation | Kontakt | Impressum | RSS Feed