Abnormal vitamin B12 metabolism in human immunodeficiency virus infection.
Association with neurological dysfunction.
Archives of neurology; VOL: 48 (3); p. 312-4
Kieburtz KD; Giang DW; Schiffer RB; Vakil N
An increased prevalence of vitamin B12 deficiency has been reported
in patients infected by the human immunodeficiency virus (HIV). We report
an unexpectedly high prevalence (20%) of such abnormal vitamin B12 metabolism
in a population of HIV-infected patients referred for neurological evaluation.
This abnormality was associated with both peripheral neuropathy and myelopathy.
A majority of those treated with cyanocobalamin had a therapeutic response.
Selected neuropathological results suggest a relationship between vitamin
B12 deficiency and vacuolar myelopathy. Vitamin B12 deficiency may be
a frequent and treatable cause of neurological dysfunction in patients
with HIV infection.