Ascorbic acid effect on intestinal iron absorption
in different types of anaemias.
El-Hawary MF; El-Shobaki FA; Kholeif T; Sakr R; El-Bassousy EM; Abdel-Khalek
K; Khashaba A Gaz Egypt Paediatr Assoc 1975 Apr;23(2):145-9
The study deals with investigations on anaemia due to iron or protein
calorie deficiency and that associating acute glomerulonephritis, nephrosis
and schistosoma haematobium. The rate of intestinal iron absorption using
an oral dose of ferrous sulphate equivalent to 4 mg clemental iron/kg
body weight was studied. The supplementing action of ascorbic acid in
iron absorption in these cases was also investigated. The rate of intestinal
iron absorption was enhanced in pure iron deficiency anaemia, acute glomerulonephritis
and schistosoma haematobium, retarded in kwashiorkor, marasmus and nephrosis.
Ascorbic acid markedly promoted iron absorption in normal subjects but
slightly in pure iron deficiency anaemia. It improved iron absorption
in acute glomerulonephritis and schistosoma haematobium but not in kwashiorkor,
marasmus and nephrotic cases. It is concluded that ascorbic acid
supplementation is of certain beneficial effect in alleviating the state
of anaemia when intestinal iron absorption is not impaired. Also, it may
prove to be of value to be given along with protein rehabilitation in
anaemias associating protein deficiency.