"The effect of niacinamide on osteoarthritis: a pilot study."
Jonas WB; Rapoza CP; Blair WF; Inflamm Res 1996 Jul;45(7):330-4.
ABSTRACT: OBJECTIVE: To evaluate the effect of niacinamide, on selected
parameters of osteoarthritis using a double-blind, placebo controlled
METHODS: Seventy two patients with osteoarthritis were randomized for
treatment with niacinamide or an identical placebo for 12 weeks. Outcome
measures included global arthritis impact and pain, joint range of motion
and flexibility, erythrocyte sedimentation rate, complete blood count,
liver function tests, cholesterol, uric acid, and fasting blood sugar.
Compliance was monitored with a pill record sheet and interview. RESULTS:
Global arthritis impact improved by 29% (95% confidence interval [CI]
6, 46) in subjects on niacinamide and worsened by 10% in placebo subjects
(p = 0.04). Pain levels did not change but those on niacinamide
reduced their anti-inflammatory medications by 13% (95% CI 9,
94; p = 0.01). Niacinamide reduced erythrocyte sedimentation rate by 22%
(95% CI 6, 51; p < 0.005) and increased joint mobility by 4.5 degrees
over controls (8 degrees vs 3.5 degrees; p = 0.04). Side effects were
mild but higher in the niacinamide group (40% vs 27%, p = 0.003). CONCLUSION:
This study indicates that niacinamide may have a role in the treatment
of osteoarthritis. Niacinamide improved the global impact of osteoarthritis,
improved joint flexibility, reduced inflammation, and allowed for reduction
in standard anti-inflammatory medications when compared to placebo.
More extensive evaluation of niacinamide in arthritis is warranted