Rheumatoid arthritis, Oxidant/antioxidant status
"Oxidant/antioxidant status of plasma samples from patients with
Ozturk HS; Cimen MY; Cimen OB; Kacmaz M; Durak I; Rheumatol Int 1999;19(1-2):35-7.
ABSTRACT: This study aims to elucidate plasma oxidant/antioxidant
status in patients with rheumatoid arthritis (RA). Fasting blood samples
were obtained from 24 patients with RA and 20 control subjects. Antioxidant
potential (AOP) value, nonenzymatic superoxide radical scavenger activity
(NSSA), and malondialdehyde (MDA) levels were measured to establish plasma
oxidant/antioxidant status in the patient and control groups. Patients
with RA had lower AOP and NSSA but higher MDA levels than those of the
control subjects, which was an indication of reduced antioxidant
capacity and oxidant stress in these patients. Results suggest
that the antioxidant system is impaired and peroxidation reactions are
accelerated in patients with RA. We suppose that therapeutic use
of some antioxidants may be beneficial in this regard.