ASTHMA AND MAGNESIUM
"Magnesium Sulfate Is Effective for Severe Acute Asthma Treated
in the Emergency Department"
Rowe BH, et al, WJM, February, 2000;172:96.-
7 trials of magnesium sulfate infusion encompassing 665 patients, of which
5 were adult trials and 2 were pediatric, analyses of patients with severe
asthma showed a reduction in hospital admission rates, whereas there was
no difference shown for patients with mild-to-moderate asthma. This study
showed no difference in pulmonary function or vital signs. In studies
of patients with severe asthma, the peak expiratory flow rate improved
by 52 l/min and the forced expiratory volume in 1 second by 8% of the
predicted value. Intravenous magnesium sulfate reduced the rate
of hospital admissions and improved pulmonary function in patients with
severe asthma treated in the emergency department.