>> HOMEPAGE

Coronary Heart Disease

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease.

Heitzer T; Schlinzig T; Krohn K; Meinertz T; Munzel T
Circulation 2001 Nov 27;104(22):2673-8

BACKGROUND: Endothelial function is impaired in coronary artery disease and may contribute to its clinical manifestations. Increased oxidative stress has been linked to impaired endothelial function in atherosclerosis and may play a role in the pathogenesis of cardiovascular events. This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease. METHODS AND RESULTS: Endothelium-dependent and -independent vasodilation was determined in 281 patients with documented coronary artery disease by measuring forearm blood flow responses to acetylcholine and sodium nitroprusside using venous occlusion plethysmography. The effect of the coadministration of vitamin C (24 mg/min) was assessed in a subgroup of 179 patients. Cardiovascular events, including death from cardiovascular causes, myocardial infarction, ischemic stroke, coronary angioplasty, and coronary or peripheral bypass operation, were studied during a mean follow-up period of 4.5 years. Patients experiencing cardiovascular events (n=91) had lower vasodilator responses to acetylcholine (P<0.001) and sodium nitroprusside (P<0.05), but greater benefit from vitamin C (P<0.01). The Cox proportional regression analysis for conventional risk factors demonstrated that blunted acetylcholine-induced vasodilation (P=0.001), the effect of vitamin C (P=0.001), and age (P=0.016) remained independent predictors of cardiovascular events. CONCLUSIONS: Endothelial dysfunction and increased vascular oxidative stress predict the risk of cardiovascular events in patients with coronary artery disease. These data support the concept that oxidative stress may contribute not only to endothelial dysfunction but also to coronary artery disease activity.

Sitemap

Was ist neu:

Mikronährstoffe können vor Zellschäden durch Strahlung schützen

Bildgebende Diagnostik kann in Zellen Strahlungsschäden verursachen

Erhöhte Cholesterinspiegel natürlich senken, ohne Medikamente

Herzrhythmusstörungen auf natürliche Weise vorbeugen bzw. korrigieren

Niereninsuffizienz und deren natürlicher Behandlungsansatz

ADHS natürlich behandeln

Versichertenentlastungsgesetz und Pflege-Sofortprogramm: neue Nebelkerzen – Ursachen bleiben

Herz-Kreislauf-Erkrankungen natürlich vorbeugen – ohne Medikamente!

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2018 Dr. Rath Health Foundation | Kontakt | Impressum | Nutzungsbedingungen | Datenschutzerklärung | RSS Feed