A deficiency of vitamin B6 is a plausible molecular basis of the retinopathy
of patients with diabetes mellitus.
Ellis JM; Folkers K; Minadeo M; Van Buskirk R; Xia LJ; Tamagawa
Biochem Biophys Res Commun 1991 Aug 30;179(1):615-9
Eighteen patients with diabetes mellitus, some of whom had variously
retinopathy, pregnancy, and the carpal tunnel syndrome, and were variously
treated with steroids and vitamin B6, have been overviewed for periods
of 8 months to 28 years. We have established an association of a deficiency
of vitamin B6 with diabetes by monitoring the specific activity of the
erythrocyte glutamic oxaloacetic transaminase and again by the association
with the carpal tunnel syndrome (C.T.S.). It has been known for a decade
that C.T.S. is caused by a B6 deficiency. The absence of retinopathy in
vitamin B6-treated diabetic patients over periods of 8 months - 28 years
appears monumental. These observations are like discovery and constitute
a basis for a new protocol to establish the apparent relationship of a
deficiency of vitamin B6 as a molecular cause of diabetic neuropathy.
Blindness and vision are so important that the strength or weakness of
the observations are not important; the conduct of a new protocol is important.