>> HOMEPAGE

Heart Failure

Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment.

Morisco C; Nappi A; Argenziano L; Sarno D; Fonatana D; Imbriaco M; Nicolai E; Romano M; Rosiello G; Cuocolo A

Molecular Aspects of Medicine 1994;15 Suppl:s155-63

In patients with chronic heart failure (CHF), the addition of coenzyme Q10 to conventional therapy reduces the hospitalization rate for worsening of heart failure and the incidence of serious cardiovascular complications. The present study was planned to assess the hemodynamic mechanisms underlying this phenomenon. Cardiac hemodynamics was evaluated continuously using an ambulatory radionuclide detector (VEST) which allows a noninvasive monitoring of left ventricular function. Six patients wit CHF (mean ejection fraction (EF): 29%) clinically documented were studied. This study was organized as a randomized double-blind, placebo controlled, cross-over trial. The enrolled patients, after a washout period, underwent the first hemodynamic evaluation with VEST. Subsequently they were randomized to receive placebo or coenzyme Q10 for 4 weeks. At the end of this period they underwent the second VEST study. The third VEST study was performed after a further 4-week period with inverted treatment. Cardiac hemodynamics were evaluated during bicycle exercise. The EF in control conditions (CC) changed from 27 +/- 11%, at rest, to 24 +/- 8%, at peak exercise. During coenzyme Q10 treatment EF showed a significant increase both at rest (33 +/- 13%, P < 0.05 vs CC) and at peak exercise (30 +/- 12%, P < 0.05 vs CC). The same trends were recorded for the stroke volume and the cardiac output. Our results demonstrate that coenzyme Q10 improves cardiac hemodynamic response to exercise in patients with CHF and suggest that noninvasive monitoring of left ventricular function allows a more reliable assessment of therapy efficacy.

Sitemap

Was ist neu:

Noch mehr Belege für den Stellenwert von Nährstoffen bei Psychose und Schizophrenie

Neue Meta-Analyse bestätigt: Vitamine reduzieren ‚dramatisch’ das Risiko für tödlichen Pankreaskrebs

Miese Nachrichten für die Pharma: Präventive Gesundheitsansätze und Wandel im Gesundheitswesen sind unaufhaltbar

Europäische Behörden genehmigen die Bayer-Übernahme des GMO/Pestizid-Riesen Monsanto

Vitamin C und andere Nährstoffe wirksam bei lebensbedrohlicher Sepsis und septischem Schock

Die amerikanische Opiod-Epidemie: Zeit, das Pharmakartell wie das Tabakkartell zu behandeln

Stillstand 4.0 – GroKo verschleppt Modernisierung des Gesundheitswesens

„Ich verstehe Dich“ – Warum aktives Zuhören der erste Schritt zur Gesundheit ist

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2018 Dr. Rath Health Foundation | Kontakt | Impressum | RSS Feed