>> HOMEPAGE

Heart Failure

Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment.

Morisco C; Nappi A; Argenziano L; Sarno D; Fonatana D; Imbriaco M; Nicolai E; Romano M; Rosiello G; Cuocolo A

Molecular Aspects of Medicine 1994;15 Suppl:s155-63

In patients with chronic heart failure (CHF), the addition of coenzyme Q10 to conventional therapy reduces the hospitalization rate for worsening of heart failure and the incidence of serious cardiovascular complications. The present study was planned to assess the hemodynamic mechanisms underlying this phenomenon. Cardiac hemodynamics was evaluated continuously using an ambulatory radionuclide detector (VEST) which allows a noninvasive monitoring of left ventricular function. Six patients wit CHF (mean ejection fraction (EF): 29%) clinically documented were studied. This study was organized as a randomized double-blind, placebo controlled, cross-over trial. The enrolled patients, after a washout period, underwent the first hemodynamic evaluation with VEST. Subsequently they were randomized to receive placebo or coenzyme Q10 for 4 weeks. At the end of this period they underwent the second VEST study. The third VEST study was performed after a further 4-week period with inverted treatment. Cardiac hemodynamics were evaluated during bicycle exercise. The EF in control conditions (CC) changed from 27 +/- 11%, at rest, to 24 +/- 8%, at peak exercise. During coenzyme Q10 treatment EF showed a significant increase both at rest (33 +/- 13%, P < 0.05 vs CC) and at peak exercise (30 +/- 12%, P < 0.05 vs CC). The same trends were recorded for the stroke volume and the cardiac output. Our results demonstrate that coenzyme Q10 improves cardiac hemodynamic response to exercise in patients with CHF and suggest that noninvasive monitoring of left ventricular function allows a more reliable assessment of therapy efficacy.

Sitemap

Was ist neu:

Arzneimittelverschmutzung beeinträchtigt Nahrungskette, Wasserversorgung und Umwelt

Höhere Vitamin-D-Spiegel sind einer Studie zufolge mit besserer sportlicher Leistungsfähigkeit verknüpft

Krebspatientinnen erleiden laut einer Studie mehr Nebenwirkungen durch die Chemo-Giftkur

Ungeklärte Geburtsdefekte in Frankreich mehren den Verdacht auf Vertuschung durch Pestizid-Industrie

Mikronährstoffe sind notwendig für ein gesundes Skelettsystem

Die Vorteile von Mikronährstoffen: Wundheilung und gesunde Haut

Neue Studie erkennt in vitaminreicher Mittelmeer-Diät das Potential zur Vermeidung von Depressionen

Die Vorteile von Mikronährstoffen bei Borreliose: Teil 2

Die Vorteile von Mikronährstoffen bei Borreliose: Teil 1

Anfang vom Ende des Pharma-Kartells: Eine Industrie am Rande des völligen Niedergangs

Neue Studie bezieht potentiell tödliche Muskelerkrankung auf cholesterinsenkende Medikamente

Osteoporose natürlich vorbeugen und ohne Medikamente kontrollieren

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2018 Dr. Rath Health Foundation | Kontakt | Impressum | Datenschutzerklärung | RSS Feed