High Blood Pressure
Disturbed calcium metabolism in subjects with elevated diastolic blood
Reichel H; Liebethal R; Hense HW; Schmidt-Gayk H; Ritz E
Clin Investig 1992 Sep;70(9):748-51
Essential hypertension has been associated with disturbed calcium metabolism,
but the available data are controversial. We measured parameters of calcium
metabolism in groups of untreated male subjects (n = 78) with elevated
diastolic blood pressure (101 +/- 6 mmHg, mean +/- SD) and age-matched
male subjects (n = 79) with low diastolic blood pressure (62 +/- 4 mmHg).
The participants of the study were drawn from a random population sample.
Subjects with high diastolic blood pressure had significantly higher carboxy-terminal
parathyroid hormone (PTH) plasma concentrations than controls with low
diastolic blood pressure (median 114 vs. 43 pmol/l, P less than 0.01).
The 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations were
comparable in both groups. Individuals with high diastolic blood pressure
had significantly lower total serum calcium (2.41 +/- 0.10 vs. 2.47 +/-
0.10 mmol/l, mean +/- SD; P less than 0.01). PTH concentrations were correlated
with diastolic pressure (r = -0.39, P less than 0.001). The data are compatible
with increased parathyroid activity despite unchanged concentrations of
vitamin D metabolites in human hypertension.