High Blood Pressure
Effect of oral pyridoxine hydrochloride supplementation on arterial
blood pressure in patients with essential hypertension.
Aybak M; Sermet A; Ayyildiz MO; Karakilcik AZ
Arzneimittelforschung 1995 Dec;45(12):1271-3
The purpose of this study was to test the effect of vitamin B6 (pyridoxine-HCl,
CAS 58-56-0) supplementation on arterial blood pressure in essential hypertension.
The trial comprised 9 normotensive subjects (7 men and 2 women, aged between
32-58 years; mean +/- SD, 48 +/- 11) and 20 patients with essential hypertension
(16 men and 4 women, aged between 32-69 years; mean +/- SD, 56 +/- 12).
The patients were treated during 4 weeks with a single oral dose of pyridoxine
(5 mg/kg body weight/day). After a 5-min rest, measurements were made
in the supine position. When compared with the normotensive subjects,
the hypertensive subject group had a significantly higher systolic and
diastolic blood pressure (p < 0.001) and higher level of plasma norepinephrine
(NE) (p < 0.01) before pyridoxine treatment. On the other hand, there
were no significant differences in plasma epinephrine (E) and heart rates.
Treatment of hypertensive patients with pyridoxine significantly reduced
systolic (p < 0.01) and diastolic blood pressure (p < 0.005), plasma
NE (p < 0.005) and E (p < 0.05) within 4 weeks. However, there was
no significant difference in heart rate at the end of pyridoxine treatment.
These results indicate a relationship between pyridoxine status and arterial
blood pressure in the essential hypertensive patients.