Vitamin E status, glutathione peroxidase activity and the effect of
vitamin E supplementation in children with thalassemia.
Suthutvoravut U; Hathirat P; Sirichakwal P; Sasanakul W; Tassaneeyakul
A; Feungpean B
J Med Assoc Thai 1993 Oct;76 Suppl 2:146-52
Vitamin E and selenium
statuses were studied in thalassemic children in comparison with 16 normal
controls. Twelve Hb H disease, 46 beta-thal/Hb E and 7 beta-thal major
patients had lower plasma vitamin E level than controls but plasma vitamin
E/total lipids ratio of Hb H disease subjects was not different from normal.
Twelve Hb H disease and 33 beta-thal/Hb E patients had normal RBC Se but
increased RBC GSH-Px activity. Ten vitamin E-deficient thalassemic subjects
had been supplemented with 200 mg of oral vitamin E for 4-8 weeks. After
supplementation, their plasma vitamin E increased and H2O2 hemolysis decreased
to normal values. Their RBC GSH-Px activity also decreased but hematocrit
did not change significantly. The results demonstrate that some types
of thalassemic patients have vitamin E deficiency and support that vitamin
E and selenium have related functions in the prevention of RBC oxidation.
Vitamin E supplementation increased RBC resistance to oxidative damage.