Micronutrients and the pathogenesis of human immunodeficiency virus
Semba RD; Tang AM
British Journal of Nutrition 1999 Mar;81(3):181-9
deficiencies may be common during human immunodeficiency virus (HIV) infection.
Insufficient dietary intake, malabsorption, diarrhoea, and impaired storage
and altered metabolism of micronutrients can contribute to the development
of micronutrient deficiencies. Low plasma or serum levels of vitamins
A, E, B6, B12 and C, carotenoids, Se, and Zn are common in many HIV-infected
populations. Micronutrient deficiencies may contribute to the pathogenesis
of HIV infection through increased oxidative stress and compromised immunity.
Low levels or intakes of micronutrients such as vitamins A, E,
B6 and B12, Zn and Se have been associated with adverse clinical outcomes
during HIV infection, and new studies are emerging which suggest that
micronutrient supplementation may help reduce morbidity and mortality
during HIV infection.