>> HOMEPAGE

Infectious Diseases

Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania.

Fawzi WW; Msamanga GI; Spiegelman D; Urassa EJ; McGrath N; Mwakagile D; Antelman G; Mbise R; Herrera G; Kapiga S; Willett W; Hunter DJ
Lancet 1998 May 16;351(9114):1477-82

BACKGROUND: In HIV-1-infected women, poor micronutrient status has been associated with faster progression of HIV-1 disease and adverse birth outcomes. We assessed the effects of vitamin A and multivitamins on birth outcomes in such women. METHODS: In Tanzania, 1075 HIV-1-infected pregnant women at between 12 and 27 weeks' gestation received placebo (n=267), vitamin A (n=269), multivitamins excluding vitamin A (n=269), or multivitamins including vitamin A (n=270) in a randomised, double-blind, placebo-controlled trial with a 2x2 factorial design. We measured the effects of multivitamins and vitamin A on birth outcomes and counts of T lymphocyte subsets. We did analyses by intention to treat. RESULTS: 30 fetal deaths occurred among women assigned multivitamins compared with 49 among those not on multivitamins (relative risk 0.61 [95% CI 0.39-0.94] p=0.02). Multivitamin supplementation decreased the risk of low birthweight (<2500 g) by 44% (0.56 [0.38-0.82] p=0.003), severe preterm birth (<34 weeks of gestation) by 39% (0.61 [0.38-0.96] p=0.03), and small size for gestational age at birth by 43% (0.57 [0.39-0.82] p=0.002). Vitamin A supplementation had no significant effect on these variables. Multivitamins, but not vitamin A, resulted in a significant increase in CD4, CD8, and CD3 counts. INTERPRETATION: Multivitamin supplementation is a low-cost way of substantially decreasing adverse pregnancy outcomes and increasing T-cell counts in HIV-1-infected women. The clinical relevance of our findings for vertical transmission and clinical progression of HIV-1 disease is yet to be ascertained.

Sitemap

Was ist neu:

Die Cholesterin-Herzinfarkt-Hypothese ist “tot”, bestätigt die britische Königliche Pharmazeutische Gesellschaft

Erfrischung pur – Über die Bedeutung von Trinkwasser im menschlichen Körper

Kommissionspräsident Jean-Claude Juncker brandmarkt das ‚Brüsseler EU’-Parlament als „lächerlich

Zehn Gründe, weshalb unter der Brüsseler EU eine präventive Gesundheitsversorgung

Mentale Stärke: Innere Glaubenssätze und deren Auswirkung auf die Gesundheit

Aspirin: Die Gefahr schwerer Blutungen und das Todesrisiko sind weit höher als zuvor gedacht

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2017 Dr. Rath Health Foundation | Kontakt | Impressum | RSS Feed