>> HOMEPAGE

Arrhythmia

Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation.

Ceremuzynski L; Gebalska J; Wolk R; Makowska E

J Intern Med 2000 Jan;247(1):78-86

OBJECTIVE: To assess the role of electrolyte imbalance in cardiac arrhythmias associated with congestive heart failure. DESIGN: Serum magnesium and potassium levels, urine magnesium excretion and the incidence of ventricular arrhythmias were assessed throughout the study. The patients who displayed complex arrhythmias after the first week of hospital medication were randomized 2:1 to double-blind magnesium supplementation or placebo. SETTING: The study was carried out in one municipal hospital, providing primary care. SUBJECTS: A total of 588 consecutive patients were screened for eligibility (clinical heart failure >/=6 months; NYHA class II-IV; left ventricular ejection fraction </=40%; sinus rhythm; serum creatinine </=2 mg dL-1). A total of 78 patients entered and 68 patients completed the study. INTERVENTIONS: Intravenous administration of magnesium (magnesium sulphate 8 g in 250 mL of 5% glucose) or placebo (250 mL of 5% glucose) over 12 h. MAIN OUTCOME MEASURES: (i) Incidence of ventricular arrhythmias in patients with hypomagnesemia; (ii) effects of magnesium supplementation on ventricular arrhythmias. RESULTS: On admission, hypomagnesemia was found in 38% and excessive magnesium loss in 72% of patients. Serum magnesium levels were lower and urine magnesium excretion was greater in patients with complex ventricular arrhythmias, both on admission and after treatment for heart failure. Intravenous administration of magnesium caused a significant decrease in the number of ventricular ectopic beats (P < 0.0001), couplets (P < 0.003) and episodes of nonsustained ventricular tachycardia (P < 0.01). CONCLUSIONS: Hypomagnesemia, probably related to increased urine magnesium excretion, is an essential feature of heart failure associated with complex ventricular arrhythmias. These arrhythmias can be alleviated/abolished by magnesium supplementation.

Sitemap

Was ist neu:

Unsere Verantwortung für die Schaffung einer Welt der Gesundheit, des Friedens und der sozialen Gerechtigkeit

Neue Studie würdigt die Rolle von Vitamin C bei der Reduktion von herzkreislaufbedingter Sterblichkeit

Mehr Kranke bitte! – Abrechnungsbetrügerei mit System

Wenn Arzneimittel verpflichtend werden: Pharma stiftet Gerichte dazu an, Opiod-Abhängige einem Drogenprogramm zu unterwerfen – mit Kosten von $1000 je Injektion

Depressionen infolge Vitamin B-Mangel – ein neuer wissenschaftlicher Review steigert die Beweislast

Neue Metaanalyse stellt wiederum den Nutzen von Magnesium bei Bluthochdruck unter Beweis

Die Cholesterin-Herzinfarkt-Hypothese ist “tot”, bestätigt die britische Königliche Pharmazeutische Gesellschaft

Erfrischung pur – Über die Bedeutung von Trinkwasser im menschlichen Körper

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2017 Dr. Rath Health Foundation | Kontakt | Impressum | RSS Feed