>> HOMEPAGE

Arrhythmia

Beneficial effects of vitamin E treatment in acute myocardial infarction.

Sethi R; Takeda N; Nagano M; Dhalla NS

J Cardiovasc Pharmacol Ther 2000 Jan;5(1):51-8

BACKGROUND: Vitamin E (Vit E), an antioxidant, is considered to prolong survival in patients and animals after myocardial infarction. Because myocardial infarction is associated with arrhythmia and heart dysfunction, this study tested the hypothesis that early treatment with Vit E reduces mortality because of its protective effects against arrhythmia and cardiac dysfunction induced by acute myocardial infarction. METHODS: Rats were randomly divided into 4 groups: sham control, myocardial infarcted, Vit E-treated sham control, and Vit E-treated infarcted animals. Myocardial infarction was induced by ligation of the left anterior descending coronary artery. Treated animals received Vit E (25 mg/kg/d) through a gastric tube beginning 1 hour after the coronary occlusion, whereas control rats received tap water. RESULTS: Electrocardiograms (lead II) at 1, 3, 7, and 21 days after coronary occlusion in the untreated animals showed ST-segment elevation, abnormal Q waves, premature ventricular complex (PVC), and QTc prolongation. Conversely, Vit E-treated rats showed attenuated ST-segment changes, fewer abnormal Q waves, and decreased incidence of PVC after coronary occlusion. Total mortality was reduced from 38% to 16%, whereas the infarct size was decreased from 44.2% to 22.3% in infarcted rats treated with Vit E. The depression in left ventricular function as well as elevation of malondialdehyde content and conjugated diene formation in the 21-day infarcted rat hearts were prevented by Vit E treatment. CONCLUSION: These results indicate that Vit E may exert beneficial effects on the heart by reducing oxidative stress in acute myocardial infarction.

Sitemap

Was ist neu:

ADHS natürlich behandeln

Versichertenentlastungsgesetz und Pflege-Sofortprogramm: neue Nebelkerzen – Ursachen bleiben

Herz-Kreislauf-Erkrankungen natürlich vorbeugen – ohne Medikamente!

Erfolgreiche Kontrolle von Multipler Sklerose durch Anwendung von Zellular Medizin: Ein Fallbericht

Wie Polyphenole gegen Krebs wirken: Teil 1

Wie Polyphenole gegen Krebs wirken: Teil 2

Wie sich Bluthochdruck auf natürliche Weise senken lässt

Schlaganfall – eine globale Epidemie

Diabetes und dessen natürliche Behandlung

Noch mehr Belege für den Stellenwert von Nährstoffen bei Psychose und Schizophrenie

Neue Meta-Analyse bestätigt: Vitamine reduzieren ‚dramatisch’ das Risiko für tödlichen Pankreaskrebs

Miese Nachrichten für die Pharma: Präventive Gesundheitsansätze und Wandel im Gesundheitswesen sind unaufhaltbar

» Natürliche Gesundheit

» "Geschäft m. d. Krankheit"

» Internationale Kampagne

» Dr. Raths Offene Briefe

» Studien weltweit

» Studien auf Deutsch

» Helfen Sie mit!

» Codex Alimentarius

» Dossiers

» Sitemap

Dr. Rath Health Foundation auf Facebook Dr. Rath Health Foundation auf YouTube Dr. Rath Health Foundation auf Twitter RSS
 © 2018 Dr. Rath Health Foundation | Kontakt | Impressum | Nutzungsbedingungen | Datenschutzerklärung | RSS Feed