Arrhythmia
Plasma levels of antioxidant vitamins and oxidative stress in patients
with acute myocardial infarction.
Singh RB; Niaz MA; Sharma JP; Kumar R; Bishnoi I; Begom R
Acta Cardiol 1994;49(5):441-52
Of 138 patients with suspected acute myocardial infarction (AMI), 29
were excluded. Remaining 109 patients and 182 healthy controls of similar
age and sex and same population were studied in detail for demographic
variables, clinical and biochemical data for comparison. Mean age, sex,
body weight, body mass index and blood pressures were comparable in the
two groups whereas blood lipids, blood glucose and cardiac enzymes were
raised in AMI patients compared to controls. Mean levels of vitamin C,
E, A and beta-carotene were significantly less in AMI patients than controls
whereas the lipid peroxides were significantly higher in AMI patients.
The reduction in vitamin C and beta-carotene was more marked than decrease
in other vitamins. With in AMI patients, those 28 patients who had cardiac
arrhythmias showed greater decrease in vitamins compared to rest of the
patients. Within both groups, smokers and diabetes patients had greater
reduction in vitamin C and beta-carotene than other patients and subjects
without confounding factors. Smokers also had higher lipid peroxides level
than non-smokers. The inverse relation between AMI and low plasma vitamin
levels remained significant after exclusion of patients with smoking and
diabetes. These findings suggest that vitamin deficiency may be a risk
factor of AMI and these patients may benefit by administration of these
antioxidant vitamins for primary and secondary prevention of coronary
artery disease. |