Mechanism of protection induced by vitamin A in falciparum malaria.
Serghides L; Kain KC
Lancet 2002 Apr 20;359(9315):1404-6
Supplementation with vitamin
A potentiates host resistance to malaria, however, the underlying mechanism
is unknown. We tested the effects of 9-cis-retinoic acid, a metabolite
of vitamin A, on CD36 expression, non-opsonic phagocytic clearance of
parasitised erythrocytes, and TNFalpha production in human monocytes and
macrophages. We found reduced secretion of TNFalpha, upregulated CD36
expression, and increased phagocytosis of Plasmodium falciparum-parasitised
erythrocytes. Increased parasite clearance and reduced proinflammatory
cytokine responses to infection might partly explain the beneficial effects
of supplementation with vitamin A in malaria.