"High Dose Antioxidant Supplementation to MS Patients: Effects
on Glutathione Peroxidase, Clinical Safety, and Absorption of Selenium"
Mai, Jesper, et al, Biological Trace Element Research, 1990;24:109-117.
ABSTRACT: High-dose antioxidant supplementation has recently been
recommended for multiple sclerosis (MS) patients. This study tests the
clinical safety, the glutathione peroxidase (GSH-px) activity, and the
absorption of selenium during such supplementation. Eighteen MS patients
were given 6 tablets especially made for this study, equivalent to 6 mg
sodium selenite, 2 g vitamin C, and 480 mg vitamin E a day for five wk.
GSH-px, which was lower than in non-MS controls before the start of treatment,
increased fivefold during 5 wk of treatment. Side effects were scarce.
Ten MS patients were subjected to a 24-h selenium absorption study after
ingestion of 2 active tablets, equivalent to 2 mg sodium selenite. Selenium,
which was low initially, increased 24% during the first 3 h and then stabilized.
It is concluded that the tested antioxidant treatment seems to be safe
and that MS patients have low GSH-px, which may be increased by the tested