Baig, Shahid, M. and Qureshi, G. Ali, Biogenic Amines, 1995;11(6):479-485.
"Homocysteine and Vitamin B12 in Multiple Sclerosis"
In evaluating CSF and blood levels in 16 multiple sclerosis patients
between 20 and 63 years of age (12 females), it was found that the mean
values of vitamin B12 in the serum and cerebrospinal fluid in MS patients
were significantly lower than in healthy subjects. Mean homocysteine levels
in the serum and CSF in multiple sclerosis patients were significantly
higher as compared to healthy subjects. MS patients are particularly prone
to vitamin B12 deficiency resulting in elevated homocysteine levels which
seem to justify vitamin B6 and B12 therapy.