Nawar O; Akridge RE; Hassan E; el Gazar R; Doughty BL; Kemp WM
The effect of zinc deficiency on granuloma formation, liver fibrosis,
and antibody responses in experimental schistosomiasis.
Am J Trop Med Hyg 1992 Sep;47(3):383-9
The influence of various
dietary zinc levels on the fibrotic aspects of granuloma formation and
on the humoral response to schistosome egg antigens was investigated in
C57Bl/6 mice by feeding groups of animals zinc-deficient diets. At six
weeks of age, control and zinc-deficient mice were exposed individually
to 50-60 cercariae of the Brazilian LE strain of Schistosoma mansoni.
The animals were maintained on their respective diets for eight weeks
postinfection, then all animals were killed and analyzed for body weight,
spleen weight, collagen content of the liver, in vivo granulomatous histopathology,
and antibody responses to soluble egg antigens. Zinc-deficient
mice experienced stunted growth and reduced weight gain. Granulomatous
hypersensitivity to schistosome eggs in the liver was measured
in liver histopathologic sections using morphometric analysis and was
found to be depressed in infected mice fed the moderately and
the severely zinc-deficient diets. The low level of zinc in the diet also
affected the humoral immune response of the host to schistosome egg antigens.